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It does well in an aquarium if provided with ample hiding places and plenty of room to roam. Even though it is a nocturnal animal, it will eventually learn to come out during the day to eat.
The Serpent Sea Star is very intolerant of sudden changes in oxygen levels, salinity and pH of the water, and cannot tolerate copper-based medications. The drip acclimation method is highly recommended for all Sea Stars due to their intolerability to changes in water chemistry. It should never be exposed to air while handling.
It is extremely difficult to breed in an aquarium with no distinguishing characteristics to help differentiate it from its mate.
In the aquarium, it can be fed small pieces of chopped meat, shrimp, mussel, or fish.